Our lab is interested in exploring the mechanisms regulating cell-cell interaction in the bone marrow tissue at a multicellular scale.

Several stromal components are involved in the vascular niche formation, remodelling and interaction with the haematopoietic system in health and disease. How these components participate into the development of acute hematological malignancies is a fundamental missing piece of the puzzle. 

By using intravital two-photon microscopy and tissue bioengineering, we aim at deciphering the role of specific molecular mediators of these processes in the context of acute leukemia development.